Association Between Development of Transient Tachypnea of Newborn and Cortisole, Epinephrine and Thyroid Hormones Levels in Late Preterm and Term Newborns
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Original Article
P: 358-369
December 2020

Association Between Development of Transient Tachypnea of Newborn and Cortisole, Epinephrine and Thyroid Hormones Levels in Late Preterm and Term Newborns

J Curr Pediatr 2020;18(3):358-369
1. Mengücek Gazi Eğitim Araştırma Hastanesi, Çocuk Sağlığı ve Hastalıkları Kliniği, Kütahya, Türkiye
2. Kütahya Üniversitesi Sağlık Tıp Bilimleri Fakültesi, Neonatoloji, Kütahya, Türkiye
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Received Date: 21.06.2020
Accepted Date: 26.09.2020
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ABSTRACT

CONCLUSIONS:

In our study;In our study; when the group diagnosed with TTN was compared with the control group, TSH and epinephrine levels were found to be low, but unlike the literature, there was no difference in the levels of cortisol, fT3 and fT4. With these results; we think that TSH and epinephrine may be effective in regulating fetal lung fluid absorption and postnatal pulmonary adaptation mechanism.

RESULTS:

There was no difference in demographic characteristics between the groups (p> 0.05), and the risk of developing TTN was determined highly in the elective C/S group (p <0.05). Although serum cortisol levels there was no statistically significant difference; the sT4 and sT3 levels were similar. TSH and epinephrine levels were significantly lower in the newborn group diagnosed with TTN (p <0.05). Altough cortisol, epinephrine and TSH hormone levels were lower in the late preterm patient group compared to the control group (p <0.05); sT3 sT4 levels were found to be similar (p> 0.05). There was no significant difference between term patient group and control group hormone levels (p> 0.05).

MATERIALS and METHODS:

90 newborns, including term (n: 25), late preterm (n: 20) patient diagnosed of TTN and control group (n: 45), were included in the study. Gestational week, type of delivery (elective cesarean section(C/S), activated C/S, vaginal), gender, birth weight, Apgar scores and maternal characteristics were recorded. Blood samples were obtained from the patients for serum cortisol, epinephrine, fT4, fT3 and TSH hormone levels between 18.- 24. hours postnatally.

INTRODUCTION:

In this study, we aimed to define the serum levels of cortisol, epinephrine, free T4 (fT4), free T3 (fT3) and thyroid stimulating hormone (TSH) in term and late preterm newborns with TTN and control group; to determine the relationship between the development of TTN and these stress hormone levels.

Keywords:
Transient tachypnea of newborn, epinephrine, cortisole, thyroid hormone.