ABSTRACT

Although QTc interval continues to be used to determine the risk of arrhythmia in children with drugs prolonging QTc, it may be significant to compare Tp-e and Tp-e/QTc ratio. However, studies involving a larger number of patients are needed to determine whether Tp-e interval and Tp-e/QTc ratio are a priority marker.

The median age of the patients in study was 155±77.2 months. The number of female patients was 33 (60%) and the number of male patients was 22. There was a statistically significant difference between leukocyte count, hemoglobin, platelet,bun, creatinine, SGPT and calcium values at the time of admission and control at the 6th hour. There was no statistically significant difference between CK-MB and troponin levels. Also, there was no statistically significant difference between QT, QTc, QT/QTc, Tp-e/QT and Tp-e/QTc intervals. But there was a statistically significant difference between Tp-e/QTc ratio and gender.

In this study, 55 patients who were admitted to Pediatric Emergency Department of Training and Research Hospital between January 2018 and August 2019 within the first 6 hours due to intoxication with QTc prolongation and followed up in our pediatric emergency department were retrospectively reviewed. In patients hospital records, age, sex, medication, time of application, clinical and physical examination findings, vital signs, treatments and results, laboratory findings, electrocardiogram findings at the time of admission hospital and in the 6. hour control, QT, QTc, Tp-e, Tp-e/QT and Tp-e/QTc times were recorded.

Childhood intoxications are among the most common reasons for admission to the emergency department. The aim of this study is to evaluate whether there is a primary marker that can determine the risk of arrhythmia by comparison of QT, QTc, QT/QTc, Tp-e/QT, Tp-e/QTc intervals in drug intoxications with prolonging QTc which can be fatal by causing arrhythmia in children.