EN | TR
E-ISSN: 1308-6308 ISSN: 1304-9054
Multiple Sclerosis in Childhood: Single Center Experience
PDF
Cite
Share
Request
Original Article
VOLUME: 19 ISSUE: 2
P: 225-230
August 2021

Multiple Sclerosis in Childhood: Single Center Experience

J Curr Pediatr 2021;19(2):225-230
DOI: 10.4274/jcp.2021.0028
Muhittin Bodur
Rabia Tütüncü Toker
Mehmet Sait Okan
1. Bursa Uludağ Üniversitesi Tıp Fakültesi, Çocuk Sağlığı ve Hastalıkları Anabilim Dalı, Çocuk Nöroloji Bilim Dalı, Bursa, Türkiye
No information available.
No information available
Received Date: 04.02.2021
Accepted Date: 24.03.2021
Publish Date: 25.08.2021
PDF
Cite
Share
Request

ABSTRACT

Conclusions:

In this study, gender, age, family history, age at onset of symptoms, initial symptoms, MR findings, CSF findings, VEP, SEP findings, treatments used, and the number of episodes were evaluated. Multicenter, prospective, and longitudinal studies with larger study populations are needed to understand multiple sclerosis onset in the pediatric period.

Results:

Of the 19 patients diagnosed with multiple sclerosis, 13 were female (68.4%), 6 were male (31.5%), and the female/male ratio was 2.16. The mean age of onset of symptoms was 14.09 years. The mean age of diagnosis was 15.2 years, and the mean follow-up period was 2.17 years. Family history was positive in 3 patients (15.7%). When the initial symptoms of our patients were examined, motor, sensory and brainstem findings were present in 11(57.8%), 9 (47.3%) and 7 cases (36.8%), respectively. Two patients (10.5%) presented with cerebellar findings and 6 patients (31.5%) with visual impairment. The oligoclonal band of CSF was found to be positive in 17 (89.4%) of the cases.

Materials and Methods:

In this study files of 23 patients with multiple sclerosis who were admitted to Department of Pediatric Neurology between January 2006 and January 2016 were investigated retrospectively. The data of 19 cases were evaluated since 3 cases were excluded due to lack of attending the control visits for more than 2 years and 1 case died in a traffic accident. Gender, current age, family history of MS, onset ages of symptoms, age at diagnosis, duration of disease follow-up, initial symptoms, magnetic resonance(MR) findings, cerebrospinal fluid(CSF) oligoclonal band positivity, visual evoked potential(VEP), somatosensory evoked potential(SEP) findings, treatments and a number of attacks were evaluated.

Introduction:

In this study, clinical and demographic features of childhood multiple sclerosis(MS) diagnosed in a single center for 10 years are presented.

Keywords:
Multiple sclerosis, childhood, treatment

References

1
O’Connor P; Canadian Multiple Sclerosis Working Group. Key issues in the diagnosis and treatment of multipl sclerosis. Neurology 2002;59(6 Suppl 3):1-33.
2
Renoux C, Vukusic S, Mikaeloff Y, Edan G, Clanet M, Dubois B, et al. Natural history of multiple sclerosis with childhood onset. N Engl J Med 2007;356:2603-13.
3
Ruggieri M, Iannetti P, Polizzi A, Pavone L, Grimaldi LM; Italian Society of Paediatric Neurology Study Group on Childhood Multiple Sclerosis. Multiple sclerosis in children under 10 years of age. Neurol Sci 2004;25:326-3.
4
Jones CT. Childhood autoimmune neurologic diseases of the central nervous system. Neurol Clin 2003;21:745-64.
5
Sluder JAD, Newhouse P, Fain D. Pediatric and adolescent multipl sclerosis. Adolesc Med 2002;13:461-85.
6
Mikaeloff Y, Suissa S, Vallée L, Lubetzki C, Ponsot G, Confavreux C, et al. First episode of acute CNS inflammatory demyelination in childhood. J Pediatr 2004;144:246-52.
7
Mikaeloff Y, Moreau T, Debouverie M, Pelletier J, Lebrun C, Gout O, et al. Interferon-beta treatment in patients with childhood-onset multipl sclerosis. J Pediatr 2001;139:443-6.
8
Poser CM, Paty DW, Scheinberg L, McDonald WI, Davis FA, Ebers GC, et al. New diagnostic criteria for multipl sclerosis. Ann Neurol 1983;13:227-31.
9
Inaloo S, Haghbin S. Multiple Sclerosis in Children. Iran J Child Neurol 2013;7:1-10.
10
Peña JA, Ravelo ME, Rubio E, Pirela D, Soto A, Nava CM. Pediatric multiple sclerosis in Venezuela. Arq Neuropsiquiatr 2012;70:267-70.
11
Boiko A, Vorobeychik G, Paty D, Devonshire V, Sadovnick D; University of British Columbia MS Clinic Neurologist. Early onset multiple sclerosis: a longitudinal study. Neurology 2002;59:1006-10.
12
Deryck O, Ketelaer P, Dubois B. Clinical characteristics and long term prognosis in early onset multiple sclerosis. J Neurol 2006;253:720-3.
13
Fragoso YD, Ferreira ML, Morales Nde M, Arruda WO, Brooks JB, Carneiro DS, et al. Multiple sclerosis starting before the age of 18 years: the Brazilian experience. Arq Neuropsiquiatr 2013;71:783-7.
14
Ghezzi A, Deplano V, Faroni J, Grasso MG, Liguori M, Marrosu G, et al. Multipl sclerosis in childhood: clinical features of 149 cases. Mult Scler 1997;3:43-6.
15
Chitnis T, Glanz B, Jaffin S, Healy B. Demographics of pediatric-onset multiple sclerosis in an MS center population from the Northeastern United States. Mult Scler 2009;15:627-31.
16
Stark W, Huppke P, Gärtner J. Paediatric multiple sclerosis: the experience of the German Centre for Multiple Sclerosis in Childhood and Adolescence. J Neurol 2008;255(Suppl 6):119-22.
17
Yeshokumar AK, Narula S, Banwell B. Pediatric multiple sclerosis. Curr Opin Neurol 2017;30.3:216-21.
18
Kaya D, Idiman E, Ozakbaş S. Inflammatory demyelinating central nervous system diseases in childhood: clinical and paraclinical profiles in 133 patients. Autoimmune Dis 2012;2012:957802.
19
Yılmaz Ü, Anlar B, Gücüyener K; Turkish Pediatric Multiple Sclerosis Study Group. Characteristics of pediatric multiple sclerosis: The Turkish pediatric multiple sclerosis database. Eur J Paediatr Neurol 2017;21:864-72.
20
Correia AS, Augusto L, Meireles J, Pinto J, Sousa AP. Pediatric multiple sclerosis in Portugal: a multicentre study. Acta Med Port 2016;29:425-31.
21
Krajnc N, Oražem J, Rener-Primec Z, Kržan MJ. Multiple sclerosis in pediatric patients in Slovenia. Mult Scler Relat Disord 2018;20:194-8.
22
Duquette P, Murray TJ, Pleines J, Ebers GC, Sadovnick D, Weldon P, et al. Multipl sclerosis in childhood; clinical profile in 125 patients. J Pediatr 1987;111:359-63.
23
Ben Achour N, Rebai I, Raddadi S, Benrhouma H, Klaa H, Rouissi A, et al. Pediatric Multiple Sclerosis in Tunisia: A Retrospective Study over 11 Years. Biomed Res Int 2017;2017: 4354826.
24
Achiron A, Garty BZ, Menascu S, Magalashvili D, Dolev M, Ben-Zeev B, et al. Multiple sclerosis in Israeli children: incidence, and clinical, cerebrospinal fluid and magnetic resonance imaging Findings. Isr Med Assoc J 2012;14:234-9.
25
Weng WC, Yang CC, Yu TW, Shen YZ, Lee WT. Multiple sclerosis with childhood onset: report of 21 cases in Taiwan. Pediatr Neurol 2006;35:327-34.
26
Etemadifar M, Nasr-Esfahani AH, Khodabandehlou R, Maghzi AH. Childhood-onset multiple sclerosis: report of 82 patients from Isfahan. Iran Arch Iran Med 2007;10:152-6.
27
Torisu H, Kira R, Ishizaki Y, Sanefuji M, Yamaguchi Y, Yasumoto S, et al. Clinical study of childhood acute disseminated encephalomyelitis, multiple sclerosis, and acute transverse myelitis in Fukuoka Prefecture, Japan. Brain Dev 2010;32:454-62.
28
Ozakbas S, Idiman E, Baklan B, Yulug B. Childhood and juvenile onset multiple sclerosis: clinical and paraclinical features. Brain Dev 2003;25:233-6.
29
Brass SD, Caramanos Z, Santos C, Dilenge ME, Lapierre Y, Rosenblatt B. Multiple sclerosis vs acute disseminated encephalomyelitis in childhood. Pediatr Neurol 2003;29:227-31.
30
Mikaeloff Y, Caridade G, Assi S, Suissa S, Tardieu M. Prognostic factors for early severity in a childhood multiple sclerosis cohort. Pediatrics 2006;118:1133-9.