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E-ISSN: 1308-6308 ISSN: 1304-9054
Evaluation of Antiemetic Therapy Used for Chemotherapy Induced Nausea and Vomiting in Children
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Review
VOLUME: 15 ISSUE: 3
P: 70-78
December 2017

Evaluation of Antiemetic Therapy Used for Chemotherapy Induced Nausea and Vomiting in Children

J Curr Pediatr 2017;15(3):70-78
DOI: 10.4274/jcp.2017.0028
Suna Emir
1. Ankara Çocuk Sağlığı ve Hastalıkları Hematoloji Onkoloji Eğitim ve Araştırma Hastanesi, Ankara
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ABSTRACT

Nausea and vomiting associated with chemotherapy is one of the important side effects of treatment in children with cancer. Despite the development of new antiemetic agents, there are still some problems in this regard in children. The combination of a 5-HT3 receptor antagonist plus a corticosteroid is usually used to prevent chemotherapy induced nausea and vomiting (CINV) in children receiving emetogenic chemotherapy. New antiemetic agents do not take part in the current pediatric guidelines. There is also no sufficient data on alternative agents in children with intractable vomiting. This review summarizes the CINV definitions in children, the classification of the antiemetic drugs as standard, newly available and optional drugs in children. Each drug category is discussed according to the mode of action, efficacy in different types of CINV, recommended dose and finally some suggestions for CINV in children.