Intrauterine Onset Ulnar Artery Thromboembolism: A Case Report
PDF
Cite
Share
Request
Case Report
P: 387-392
December 2021

Intrauterine Onset Ulnar Artery Thromboembolism: A Case Report

J Curr Pediatr 2021;19(3):387-392
1. Eskisehir Osmangazi Üniversitesi Tıp Fakültesi, Pediatri Anabilim Dalı, Neonatoloji Bilim Dalı, Eskişehir, Türkiye
2. Eskişehir Osmangazi Üniversitesi Tıp Fakültesi, Pediatri Anabilim Dalı, Çocuk Hematoloji Bilim Dalı, Eskişehir, Türkiye
No information available.
No information available
Received Date: 17.05.2021
Accepted Date: 10.10.2021
Publish Date: 24.12.2021
PDF
Cite
Share
Request

ABSTRACT

Introduction:

While neonatal thromboembolism is uncommon, it is frequently seen in newborn infants with central catheters who are monitored in the neonatal intensive care unit. There is several case reports on rare thromboembolic events that occur during the intrauterine period.

Case Report:

Our patient was a term twin infant who was diagnosed with intrauterine onset right ulnar artery thromboembolism shortly after birth. The baby was given low molecular weight heparin treatment, but limb-sparing amputation was required during follow-up. The analysis of thrombophilic genetic mutations of the infant revealed heterozygous MHTFR677C> T and FII20210G> A mutations.

Conclusion:

On the basis of heterozygous mutations, twin pregnancy has been assessed as a significant risk factor. We believe that the case presented with the literature will help clinicians gain more experience.

References

1Kenet, U. Nowak-Gottl. Venous thromboembolism in neonates and children. Clin Haematol 2012;25:333-4.
2Reverdiau-Moalic P, Delahousse B, Body G, Bardos P, Leroy J, Gruel Y. Evolution of blood coagulation activators and inhibitors in the healthy human fetus. Blood 1996;88:900.
3Andrew M, Schmidt B, Mitchell L, Paes B, Ofosu F. Thrombin generation in newborn plasma is critically dependent on the concentration of prothrombin. Thromb Haemost 1990;63:27-30.
4Tuckuviene R, Christensen AL, Helgestad J, Johnsen SP, Kristensen SR. Pediatric venous and arterial noncerebral thromboembolism in Denmark:a nation wide population-based study. J Pediatr 2011;159:663-9.
5Kenet G, Nowak-Gottl U. Bleeding and thrombosis issues in pediatric patients:current approach to diagnosis and treatment. Acta Haematol 2006;115:137-40.
6Saracco P, Parodi E, Fabris C, Cecinati V, Molinari AC, Giordano P. Management and investigation of neonatal thromboembolic events:genetic and acquired risk factors. Thromb Res 2009;123:805-9.
7Rashish G, Paes BA, Nagel K, Chan AK, Thomas S; Thrombosis and Hemostasis in Newborns (THiN) Group. Spontaneous neonatal arterial thromboembolism infants at risk, diagnosis, treatment, andoutcomes. Blood Coagul Fibrinolysis 2013;24:787-97.
8Arshad A, McCarthy MJ. Management of limb ischaemia in the neonate and infant. Eur J Vasc Endovasc Surg 2009;38:61-5.
9Lynch JK. Epidemiology and classification of perinatal stroke. Semin Fetal Neonatal Med 2009;14:245-9.
10Nowak-Göttl U, vonKries R, Göbel U. Neonatal symptomatic thromboembolism in Germany:two year survey. Arch Dis Child Fetal Neonatal Ed 1997;76:163-7.
11Carr MM, al-Qattan M, Clarke HM. Extremity gangrene in utero. J Hand Surg Br 1996;21:652-5.
12Özdemir ÖMA , Kılıç İ , Küçüktaşçı K , Gürses D , Karaca A , Oto M, et al. Congenital Arterial Thrombosis in Newborn: a Case Report. Balkan Medical Journal 2011;28:331-4.
13Nagai MK, Littleton AG, Gabos PG. Intrauterine gangrene of the lower extremity in the newborn:a report of two cases. J Pediatr Orthop 2007;27:499-503.
14Dawkins RR, Marshall TL, Rogers MS. Prenatal gangrene in association with twin-twin transfusion syndrome. Am J Obstet Gynecol 1995;172:1055-7.
15Bauer KA. (2020). Antithrombin deficiency. In: Leumg LK L, Tirnauer JS (Eds.), Uptodate. Available from https://www.uptodate.com/contents/antithrombin-deficiency?search=antitrombin%20III%20deficiency&topicRef=1355&source=see_link
16Johnson D, Rosen JM, Khoury M, Stevenson D. Infarction of the upperlimbs associated with oligohydramnios and intrauterine compression. J Hand Surg Am 1988;13:408-10.
17Vasquez P, Burd A, Mehta R, Hiatt M, Hegyi T. Resolution of peripheral artery catheter-induced ischemic injury following prolonged treatment with topical nitroglycerin ointment in a newborn:a case report. J Perinatol 2003;23:348-50.
Article is only available in PDF format. Show PDF
2024 ©️ Galenos Publishing House