EN | TR
E-ISSN: 1308-6308 ISSN: 1304-9054
Lipid Metabolism Abnormalities in Obese Children and Adolescents with Subclinical Hypothyroidism
PDF
Cite
Share
Request
Original Article
VOLUME: 19 ISSUE: 1
P: 100-105
April 2021

Lipid Metabolism Abnormalities in Obese Children and Adolescents with Subclinical Hypothyroidism

J Curr Pediatr 2021;19(1):100-105
DOI: 10.4274/jcp.2020.0014
Birgül Kırel 1
İlhan Hazer 1
Hilmi Onur Kabukçu 2
Murat Yağcı 2
Zeynep Ertürk 2
Gonca Kılıç Yıldırım 3
1. Eskişehir Osmangazi Üniversitesi Tıp Fakültesi, Çocuk Sağlığı ve Hastalıkları Anabilim Dalı, Çocuk Endokrinoloji Bilim Dalı, Eskişehir, Türkiye
2. Eskişehir Osmangazi Üniversitesi Tıp Fakültesi, Çocuk Sağlığı ve Hastalıkları Anabilim Dalı, Eskişehir, Türkiye
3. Eskişehir Osmangazi Üniversitesi Tıp Fakültesi, Çocuk Sağlığı ve Hastalıkları Anabilim Dalı, Çocuk Beslenme ve Metabolizma Bilim Dalı, Eskişehir, Türkiye
No information available.
No information available
Received Date: 29.06.2020
Accepted Date: 18.12.2020
PDF
Cite
Share
Request

ABSTRACT

Conclusions:

There is a high frequency of SH in obese children and adolescents. It was understood that obese patients had dyslipidemia and this situation became more pronounced in the presence of SH and SH contributed to the development of atherogenic lipid profile. These findings made us think that weight loss of obese patients can also improve both SH and lipid metabolism abnormalities.

Results:

The frequency of SH in the whole study group was 18.2%. When compared with reference values according to age; in the whole study group and as well as in both the groups with and without SH were found borderline high levels of median total cholesterol and LDL-C levels, high median TG levels and normal-high median HDL-C levels. Median TG/HDL-C levels were>2 in these three groups. In the SH group compared to the group without SH; serum total cholesterol levels, the frequency of hypertriglyceridemia and TG / HDL-C ratio> 2 were higher (p <0.05). Serum TSH levels were positively correlated with TG (r = 0,13, p <0,05).

Materials and Methods:

The clinical findings and laboratory results of 291 overweight / obese children and adolescents (169 girls, 122 boys) were evaluated retrospectively. Lipid and lipoprotein levels of the patients were compared according to the reference values according to age and gender and were recorded as low, normal and high. Patients with normal serum fT4 levels and TSH levels: 4.5-10 mIU / ml and not receiving sodium L-throxin treatment comprised the SH group (n = 53), and patients with normal serum T4 and TSH levels constituted the control group (n = 238). These two groups were compared in terms of lipid metabolism abnormalities.

Introduction:

Subclinical hypothyroidism (SH); is a condition in which serum free T4 (fT4) levels are within normal limits and thyroid stimulating hormone (TSH) levels are above age-related levels. In obesity, serum TSH levels increase with the increase in body mass index; Thus, the frequency of SH is reported to be high in obese patients. Hypothyroidism and obesity are the main causes of Introduction: Subclinical hypothyroidism (SH); is a condition in which serum free T4 (fT4) levels are within normal limits and thyroid stimulating hormone (TSH) levels are above age-related levels. In obesity, serum TSH levels increase with the increase in body mass index; Thus, the frequency of SH is reported to be high in obese patients. Hypothyroidism and obesity are the main causes of

Article is only available in PDF format. Show PDF
2024 ©️ Galenos Publishing House