Yenidoğandan Adolesana COVID-19 Pandemisinde Çocuklarda Kardiyak Tutulum Şekilleri
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Yenidoğandan Adolesana COVID-19 Pandemisinde Çocuklarda Kardiyak Tutulum Şekilleri

J Curr Pediatr 2021;19(3):319-327 DOI: 10.4274/jcp.2021.83798
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Giriş:

COVID-19 çocuklarda hafif seyirli bir hastalık olmakla beraber, Kawasaki benzeri hastalık ya da hiperinflamatuar durumlar ile kendini gösterebilmektedir. Biz çalışmamızda COVID-19 pandemisinde çocuklarda kardiyak tutulum sıklığı ve şekillerini ortaya koymayı amaçladık.

Gereç ve Yöntem:

Mart 2020 ile Ekim 2020 arasında SARS-CoV-2 enfeksiyonu nedeni ile pediatri kliniğimizde tedavi gören 214 hastamızdan değişik şekillerde kardiyak tutulum gözlediğimiz 17 hastayı sunmak istiyoruz. Hastaların seçilme kriterleri laboratuar (artmış troponin I), elektrokardiyografik ve ekokardiyografik bulgulara dayanmaktadır. Hastalar tedavi gördükleri birimler olan pediatri servisi, yenidoğan yoğun bakım ünitesi ve çocuk yoğun bakım ünitesi olarak üç ayrı gruba ayrılmışlardır.

Bulgular:

Kardiyak tutulum 214 hastanın %7,9’unda gözlenmiş olup bunların %88.2’sinde troponin I yüksekliği, %70,5’inde anormal elektrokardiyografi bulguları ve yine %70,5’inde anormal elektrokardiyografi bulguları saptadık. Troponin I yüksekliği saptanan hastaların %82.3’ünde beraberinde anormal elektrokardiyografi bulguları saptanırken, yine bu hastaların %76.4’ünde anormal ekokardiyografi bulguları saptadık. Yedi hasta çoklu sistem inflamatuar sendromu olarak değerlendirildi.

Sonuç:

SARS-CoV-2 enfeksiyonu tedavisi alan hastalarımızın büyük bir kısmında kardiyak tutulum tespit etmedik. Tutulum saptadığımız hastalarda ise tutulum şekli oldukça değişkenlik göstermekte idi. Lakin bu yelpazenin bir ucunda sadece troponin I yüksekliği olan hastalarımız var iken diğer ucunda ekstrakorporeal membran oksijenizasyonu tedavisine ihtiyaç duyan sol ventrikül sistolik fonksiyon bozukluğu olan hastalarımız mevcuttu.

Anahtar Kelimeler: Kardiyak tutulum, COVID-19, yenidoğan, çocuklar

Kaynakça

1

CDC COVID-19 Response Team. Coronavirus Disease 2019 in Children - United States, February 12-April 2, 2020. MMWR Morb Mortal Wkly Rep. 2020 Apr 10;69:422-426.

2

Choi S-H, Kim HW, Kang J-M, Kim DH, Cho EY. (2020) Epidemiology and clinical features of coronavirus disease 2019 in children. Clin Exp Pediatr 63:125.

3

Dong Y, Mo X, Hu Y, Qi X, Jiang F, Jiang Z, et al. (2020) Epidemiological characteristics of 2143 pediatric patients with 2019 coronavirus disease in China. J Emerg Med 58:712-3.

4

S. Soumya T. Govindan Unn i& K. G. Raghu. Impact of COVID-19 on the Cardiovascular System: A Review of Available Reports. Cardiovascular Drugs and Therapy.

5

Cui Y, Tian M, Huang D,Wang X, Huang Y, Fan L, et al. A 55-day-old female infant infected with COVID 19 presenting with pneumonia, liver injury, andheart damage. J Infect Dis.

6

Li Y, Guo F, Cao Y, Li L, Guo Y Insight into COVID-2019 for pediatricians. Pediatr Pulmonol 2020;55:E1-E4.

7

Su L, Ma X, Yu H, Zhang Z, Bian P, Han Y, et al. The different clinical characteristics of corona virus disease cases between children and their families in China-the character of children with COVID-19. Emerg Microbes 2020.

8

D’Ambrosio A, Patti G, Manzoli A, Sinagra G, Di Lenarda A, Silvestri F, et al. The fate of acute myocarditis between spontaneous improvement and evolution to dilated cardiomyopathy: a review. Heart 2001;85: 499-504.

9

Durani, Y, Egan, M, Baffa, J, Selbst, S.M, Nager, A.L. Pediatric myocarditis: Presenting clinicalcharacteristics. Am. J. Emerg. Med 2009;27:942-7.

10

Freedman, S.B, Haladyn, J.K, Floh, A, Kirsh, J.A, Taylor, G, Thull-Freedman, J. Pediatric myocarditis: Emergency department clinical findings and diagnostic evaluation. Pediatrics 2007;120: 1278-85.

11

Chang YJ, Chao HC, Hsia SH, Yan DC. Myocarditis presenting as gastritis in children. Pediatr Emerg Care 2006;22:439-40.

12

Fung, G, Luo, H, Qiu, Y, Yang, D, McManus, B. Myocarditis.Circ Res 2016;118:496-514.

13

Morgera, T, Di Lenarda, A, Dreas, L, Pinamonti, B, Humar, F, Bussani, R, Silvestri, F, Chersevani, D,Camerini, F. Electrocardiography of myocarditis revisited: Clinical and prognostic significance ofelectrocardiographic changes. Am Heart J 1992;124:455-67.

14

Xia W, Shao J, Guo Y, Peng X, Li Z, Hu D (2020) Clinical and CT features in pediatric patients with COVID-19 infection: different points from adults. Pediatr Pulmonol 55:1169-74.

15

Adrian Bogdan Dancea. Myocarditis in infants and children: A review for the paediatrician. Paediatr Child Health 2001;6:8.

16

Matthias G Friedrich, François Marcotte. Cardiac magnetic resonance assessment of myocarditis. Circ Cardiovasc Imaging 2013 Sep;6(5):833-9. doi: 10.1161/CIRCIMAGING.113.000416.

17

Health Alert Network (HAN): Multisystem Inflammatory Syndrome in Children (MIS-C) Associated with Coronavirus Disease 2019 (COVID-19).

18

World Health Organization Scientif Brief: Multisystem inflammatory syndrome in children and adolescents with COVID-19. Available at: World Health Organization Scientif Brief: Multisystem inflammatory syndrome in children and adolescents with COVID-19.

19

Royal College of Paediatrics and Child Health Guidance: Paediatric multisystem inflammatory syndrome temporally associated with COVID-19. Available at: https://www.rcpch.ac.uk/sites/default/files/2020-05/COVID-19-Paediatric-multisystem-%20inflammatory%20syndrome-20200501.pdf

20

Verdoni L, Mazza A, Gervasoni A, Martelli L, Ruggeri M, Ciuffreda M, et al. An outbreak of severe Kawasaki-like disease at the Italian epicentre of the SARS-CoV-2 epidemic: an observational cohort study. Lancet 2020;395:1771.

21

Whittaker E, Bamford A, Kenny J, Kaforou M, Jones CE, Shah P, et al. Clinical Characteristics of 58 Children With a Pediatric Inflammatory Multisystem Syndrome Temporally Associated With SARS-CoV-2. JAMA 2020;324:259.

22

Feldstein LR, Rose EB, Horwitz SM, Collins JP, Newhams MM, Son MBF, et al. Multisystem Inflammatory Syndrome in U.S. Children and Adolescents. N Engl J Med 2020;383:334.

23

Godfred-Cato S, Bryant B, Leung J, Oster ME, Conklin L, Abrams J, et al. COVID-19-Associated Multisystem Inflammatory Syndrome in Children - United States, March-July 2020. MMWR Morb Mortal Wkly Rep 2020;69:1074.

24

Belhadjer Z, Méot M, Bajolle F, Khraiche D, Legendre A, Abakka S, et al. Acute Heart Failure in Multisystem Inflammatory Syndrome in Children in the Context of Global SARS-CoV-2 Pandemic. Circulation 2020;142:429.

25

Center for Disease Control and Prevention, Center for Preparedness and Response: Multisystem Inflammatory Syndrome in Children (MIS-C) Associated with Coronavirus Disease 2019 (COVID-19), Clinician Outreach and Communication (COCA)Webinar.Availableat:https://emergency.cdc.gov/coca/calls/2020/callinfo_051920.asp?deliveryName=USCDC_1052-DM28623.

26

Natasha A. Nakra, Dean A. Blumberg, Angel Herrera-Guerra and Satyan Lakshminrusimha. Multi-System Inflammatory Syndrome in Children (MIS-C) Following SARS-CoV-2 Infection: Review of Clinical Presentation, Hypothetical Pathogenesis and Proposed Management. Children (Basel) 2020:1;7:69.

27

Grimaud M, Starck J, Levy M, Marais C, Chareyre J, Khraiche D, et al. Acute myocarditis and multisystem inflammatory emerging disease following SARS-CoV-2 infection in critically ill children. Ann Intensive Care 2020:1;10:69.

28

Afif F. EL-Khuffash, Eleanor J. Molloy. Serum Troponin in Neonatal Intensive Care. Neonatology 2008;94:1-7.

29

Baum H, Hinze A, Bartels P, Neumeier D. Reference values for cardiac troponins T and I in healthy neonates. Clin Biochem 2004;37:1079-82.

30

D Bader 1, A Kugelman, A Lanir, A Tamir, E Mula, A Riskin. Cardiac troponin I serum concentrations in newborns: a study and review of the literature. Clin Chim Acta 2006;371(1-2):61-5.

31

Caselli C, Ragusa R, Prontera C, Cabiati M, Cantinotti M, Federico G, et al. Distribution of circulating cardiac biomarkers in healthy children: from birth through adulthood. Biomark Med 2016;10:357-65.

32

Sanna G, Serrau G, Bassareo PP, Neroni P, Fanos V, Marcialis MA. Children’s heart and COVID-19: Up-to-date evidence in the form of a systematic review. Eur J Pediatr 2020;179:1079-87.

33

Hennon TR, Penque MD, Abdul-Aziz R, Alibrahim OS, McGreevy MB, Prout AJ, et al. COVID-19 associated Multisystem Inflammatory Syndrome in Children (MIS-C) guidelines; a Western New York approach. Prog Pediatr Cardiol 2020:23:101232.