Öz
Giriş
Bu çalışmada plazma amino asit düzeyleri ile çocuklarda Helicobacter pylori (H. pylori) varlığı arasındaki ilişki araştırıldı.
Gereç ve Yöntem
Çalışmaya gastriti olan 88 çocuk hasta (30 H. pylori pozitif ve 58 H. pylori negatif) ve 32 çocuktan oluşan bir kontrol grubu dahil edildi. Plazma amino asit düzeyleri sıvı kromatografisi-tandem kütle spektrometrisi kullanılarak değerlendirildi ve tüm katılımcıların diyetle amino asit alımı üç günlük diyet anketine dayanarak tahmin edildi.
Bulgular
Plazma glisin, alanin ve histidin düzeyleri H. pylori negatif grupta diğer gruplara kıyasla anlamlı derecede yüksekti (p<0,05). Plazma sistein, homosistein ve hidroksilizin düzeyleri kontrol grubunda her iki gastrit grubuna kıyasla anlamlı derecede yüksekti (p<0,05). Plazma asparagin, glutamin ve histidin düzeyleri H. pylori pozitif grupta H. pylori negatif gruba kıyasla anlamlı derecede düşük bulundu (p<0,05).
Sonuç
Bu çalışmada, asparagin, glutamin ve histidin plazma düzeyleri ile çocuklarda H. pylori gastriti varlığı arasında orta düzeyde bir korelasyon tespit edildi.
Anahtar Kelimeler: Anahtar kelimeler: Helicobacter pylori, plazma amino asitleri, gastrit, çocuk
Kaynakça
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