Öz
Giriş
Bu çalışma, SeLECTS (Self-limited epilepsy with centrotemporal spikes) tanısı almış çocukların klinik ve EEG özelliklerini incelemeyi, dikkat eksikliği hiperaktivite bozukluğu (DEHB) eşlik edip etmediğine göre antiepileptik ilaçların (AEİ) etkinliğini karşılaştırmayı ve spike-wave indeksinin (SWI) prognostik değerini değerlendirmeyi amaçlamaktadır.
Gereç ve Yöntem
2005-2023 yılları arasında SeLECTS tanısı almış 914 çocuk retrospektif olarak değerlendirildi. Dahil edilme kriterlerini karşılayan 542 çocuk çalışmaya alındı. Hastalar en az üç yıl boyunca, üç EEG kaydı ile takip edildi. SWI değerleri, AEİ türü valproik asit (VPA), karbamezapin (CBZ, levetirasetam (LEV), DEHB varlığı ve yaşa göre analiz edildi. SWI’nin EEG iyileşmesi ve nöbet kontrolü üzerindeki öngörü gücü ROC eğrisi ile değerlendirildi.
Bulgular
Ortalama yaş 8.18±3.35 yıl; erkek/kız oranı 1.47:1 idi. Beş yaş altı başlangıç, daha sık nöbet ile ilişkiliydi (p=0.003). VPA EEG iyileşmesinde; LEV ise nöbet kontrolünde daha etkiliydi. DEHB’li çocuklarda SWI daha yüksekti. Zamanla SWI değerlerinde azalma izlendi. DEHB sıklığı %19.9’du.
Sonuç
SWI, tedavi yanıtını değerlendirmede faydalı bir araçtır. DEHB eşlik eden hastalarda epilepsi yükü daha fazladır. VPA EEG normalleşmesinde, LEV nöbet kontrolünde daha başarılıdır.
Anahtar Kelimeler: Anahtar kelimeler: SeLECTS, dikkat eksikliği ve hiperaktivite bozukluğu, antinöbet ilaçları, diken-dalga indeksi, EEG, çocukluk çağı epilepsisi
Kaynakça
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