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E-ISSN: 1308-6308 ISSN: 1304-9054
Insulin-Like Growth Factor-1 and Morbidities of Prematurity: Bronchopulmonary Dysplasia, Retinopathy of Prematurity, Intraventricular Hemorrhage and Necrotizing Enterocolitis
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Original Article
VOLUME: 17 ISSUE: 2
P: 189-199
August 2019

Insulin-Like Growth Factor-1 and Morbidities of Prematurity: Bronchopulmonary Dysplasia, Retinopathy of Prematurity, Intraventricular Hemorrhage and Necrotizing Enterocolitis

J Curr Pediatr 2019;17(2):189-199
DOI: 10.4274/jcp.2019.0017
Bayram Ali Dorum 1
Nilgün Köksal 1
Hilal Özkan 1
Salih Çağrı Çakır 1
Cansu Yilmaz 2
Taner Özgür 2
Ferah Budak 3
1. Bursa Uludağ Üniversitesi Tıp Fakültesi, Çocuk Sağlığı ve Hastalıkları A.D, Neonatoloji Bilim Dalı, Bursa.
2. Bursa Uludağ Üniversitesi Tıp Fakültesi, Çocuk Sağlığı ve Hastalıkları A.D, Bursa
3. Bursa Uludağ Üniversitesi Tıp Fakültesi, İmmünoloji A.D, Neonatoloji Bilim Dalı, Bursa.
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ABSTRACT

DISCUSSION and CONCLUSION:

Strong correlations have been found between low serum IGF-1 levels during the first four weeks and development of BPD and ROP.

RESULTS:

A total of 93 infants were enrolled in the study. All these infants had the following characteristics at birth: weight 1236.11±354.06 g, and gestational age 29.43±2.10 weeks. All of the IGF-1 levels were significantly lower in the group which developed BPD or ROP (p<0.001). The patients who developed IVH and NEC also had lower IGF-1 levels.

METHODS:

We enrolled newborn infants born at a postmenstrual age of ≤32 weeks in this prospective observational cohort study. Serum IGF-1 levels were measured serially in blood samples on the 1st, 3rd, 7th, 21st, and 28th day.

INTRODUCTION:

Insulin-like growth factor-1 (IGF-1) is important for fetal and postnatal development. After premature births, serum IGF-1 concentrations rapidly decrease and can stay at much lower levels than during the intrauterine period. In this study, we aimed to ascertain whether IGF-1 is associated with morbidities of prematurity such as bronchopulmonary dysplasia (BPD), retinopathy of prematurity (ROP), intraventricular hemorrhage (IVH), and necrotizing enterocolitis (NEC), and is a useful predictor of these diseases.