ABSTRACT

B-lymphocyte progenitor cells, so-called hematogones, and mature B lymphocytes are normal bone marrow constituents, which are more prominent in the pediatric bone marrow. Increased numbers of hematogones may cause problems in diagnosis because of the morphologic features they commonly share with the neoplastic lymphoblasts of acute lymphoblastic leukemia and lymphoblastic lymphoma. However, an increase in some of hematogones due to unknown viral infections, after high dose chemotherapy had been rarely reported in the literature. We describe here a case of a three-month-old male infant with lymphocytosis associated with increased hematogones in the bone marrow due to an unknown probable viral infection.