ABSTRACT

Despite term infants have higher positive response rate to treatment, initiating early treatment will increase the rate of positive response in preterm infants.

Overall 56 neonates were enrolled. Pre-iNO, post-iNO mean airway pressure values, and oxygenation index were significantly higher in the preterm group (p < 0.05). Mean GA and birth weight of the infants who had early PH diagnosis were higher. Positive responders were more likely to have higher GA as well as higher birth weight (p < 0.05). Non-responders were mostly diagnosed with diaphragmatic hernia in term infants and with sepsis in preterm infants.

The study cohort treated with iNO between 2015 and 2019 was categorized into two groups according to the gestational age (GA) and timing of PH.

This study aimed at assessing the data of term and preterm neonates with pulmonary hypertension (PH) to characterise patients and the effectiveness of inhaled nitric oxide (iNO).